KMID : 0388419990090010081
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Konkuk Journal of Medical Sciences 1999 Volume.9 No. 1 p.81 ~ p.88
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The Predictive Value of Specific Serum Enzymes for Neurologic Outcome in Asphyxiated Newborn
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Kim Doo-San
Hong Seong-Jin Sim Jay-Gun O Myung-Ho Kim Kee-Hyuck
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Abstract
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Perinatal asphyxia is one of the most important factors contributing to neonatal morbidity and mortality. However, no clear-cut parameters exist which enable an early identification of neonates who are at risk to develop brain damage. We measured creatine kinase(CK), CK isoenzyme, AST, ALT, LDH in full term asphyxiated(n=35) and healthy(n=39) newborns at 6-10 hours after birth to establish the values of these enzymes in the retrospective diagnosis of asphyxia and if serum levels of these enzymes correlated with the abnormalities of neurosonography or auditory evoked potential. The asphyxiated newborns had significantly increased serum activities of CK-BB(93.5 ¡¾160.8 IU/L) and CK-BB£¥(11.1¡¾12.4%) compare to controls(39.2¡¾37.2 IU/L, 3.9¡¾ 3.4%). However, there were no significant differences in the enzyme activities between normal and abnormal groups of neurosonography or auditory evoked potential. It is concluded that elevated CK-BB and CK-BB£¥ are reliable indicator of the neonatal asphyxia. But the predictive value of specific enzymes for the development of neurologic disorders is not clear. Prospective long-term follow up studies are necessary to evaluate the predictive value of enzyme activities for the neurologic outcome.
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KEYWORD
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neonates, perinatal asphyxia, serum enzyme
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